We need to know about these, as we will be hearing more about them in the future.
A study published this week in the NEJM by Saver J.L., et al., Prehospital Use of Magnesium Sulfate as Neuroprotection in Acute Stroke. 372:6 Feb 5 2015, had delivery of Magnesium Sulfate( one such potential neuroprotective agent), by pre-hospital staff, within 2 hours.
This was a multi centred, randomised, double blind, placebo controlled trial. There were 1700 patients in total and they received drug or placebo in a 1:1 ratio. The patients were between 40 and 95 years old. The dosage they received was 4g over 15 minutes and then 16g over the next 24 hours. The endpoint was disability outcomes at 90 days, using a modified Rankin Scale.
The conclusion: NO significant difference in disability outcomes.
Back to the drawing board. More about this at EMCORE